Access to clean, fresh water is a privilege many may take for granted. Yet, according to the United Nations, 2.2 billion people around the world lack access to safe water. World Water Day, held annually on March 22, is dedicated to raising awareness about the global water crisis and focusing attention on Sustainable Development Goal (SDG) 6: access to water and sanitation for all by 2030. In honor of this day, we’d like to highlight the accomplishments of iGEM teams tackling the global water crisis with synthetic biology.