Starting an iGEM team and getting a project started in the iGEM Competition can be a challenge, even for returning teams. We have prepared this guide to help you understand what to expect throughout the iGEM Competition Cycle, whether this is your first time participating, or you are returning as a seasoned veteran.

You’ve formed an iGEM team. You and your teammates have decided on a project. You’re excited about the journey that lies before you. Now is the time to share the joy and excitement of your iGEM project with those who can help support and fund your team. Here are some ideas and resources to help you put together a fundraising plan.

iGEM is a journey – a journey that requires a plan. Though starting an iGEM team can seem daunting at first, here are some guidelines to help you begin.

Yeast spores are typically not considered a problem in most situations. However, yeast spores can become problematic under certain circumstances. To help mitigate this risk, all teams who want to work with spore-forming fungi, including Saccharomyces cerevisiae, must first complete a Check-In Form to get permission from iGEM’s Safety and Security Committee.

More diverse and inclusive teams produce greater innovation and overall better science. Yet, STEM (science, technology, engineering, and math) fields still exist within demographic bubbles due to the systemic and persistent exclusion of people based on gender, or ethnicity, or socioeconomic status, or other reasons. iGEM’s new purpose is to make sure that the field of synthetic biology, and all of the power that this technology holds, gets developed everywhere by everyone.

Animals are used in research for many different purposes, including as models for the human body and as test subjects for food or medicine intended for animals. Unfortunately, one of the most common reasons that teams are disqualified from the iGEM Competition is for violations of our Animal Use Policy. The policy requires that teams get approval from the Safety & Security Committee before beginning experiments involving animals or animal samples.

Joining the iGEM Competition is no easy feat, and teams face countless obstacles as they progress through an iGEM season, whether that is troubleshooting in the lab, overcoming bugs in their wiki code, or interpersonal conflicts within the team itself. Even when faced with these issues, it is important to know that you are not alone in your struggles, and here in the iGEM Community, we have generated a number of different resources that will hopefully help to lessen the challenges you may be facing.

What exactly is an “iGEM team”? Over the years, iGEM has evolved and expanded to accommodate new groups that want to participate, and to improve the iGEM experience by refining the kind and composition of teams, the roles of team members, and the sections in which the teams compete. We’ve put together some guidelines to help you understand the anatomy of an iGEM team.

Synthetic biology has unveiled a world of potential for improving the society around us. In recent years, genetic engineering tools have enabled the development of low-cost diagnostics platforms, personalized medicines, and environmentally-friendly chemical manufacturing processes. However, it is not always straightforward to know what societal problems to tackle or how to tackle them.

If you want to solve a real-world problem using synthetic biology, you can’t just study microbes. At some point, you’ll need to study people―their diverse values, opinions, and priorities―too. In addition to the basic requirement of “don’t break the rules or the law” set out in our human subjects research policy, it’s important for your team to take some time to think about how to treat every person participating in your research with respect.

Do you remember the first time you ran a successful PCR? Was it in the last few months? The last few years? Or so long ago you don’t want to admit it? For high school students, that first successful PCR might have resulted on work from this year’s iGEM project. Let that sink in for a minute…

Although surveys may seem simple and straightforward, they are often challenging to execute well. Surveys are a form of experiment, and like any experiment, they can be designed and implemented poorly.

At iGEM, it is important to give credit where credit is due. Indeed, integrity, honesty and respect are among the iGEM values that all teams are expected to uphold.

The iGEM Measurement Committee is happy to help you learn about the concepts, tools, and resources that are available to iGEM teams. In this post, we address three questions:

What is cloning and gene assembly?
Why is cloning and gene assembly important?
How is cloning and gene assembly done?

In designing your iGEM project, we encourage you to consider: Who is included in your project design? Who benefits from your research? Will anyone be disadvantaged? Although you may want your iGEM project to benefit society, even your best intentions can have unintended consequences, especially for groups that are already disadvantaged.

What is required of us in the social sciences, as in natural sciences, is to not just take someone’s word but instead analyze and evaluate the data that is presented so as to form our own judgement. This is the essence of critical thinking.

2024 witnessed a number of space happenings – from meteor showers, supermoons and the heightened visibility of the aurora borealis, to colossal rocket launches, planetary missions, the first commercial spacewalk and the first sample return from the lunar far side. Yet, among the most exciting space happenings were the accomplishments of the iGEM Space Initiative. 

Imagine a future where most cancers are prevented or even cured, where there is universal access to early detection and treatment, and where most (all?) cancer patients can expect to live cancer-free without trading the quality of life for length of life. At iGEM, teams are working to create such a future using the tools of synthetic biology. Check out these examples.

Due to their inherent safety, simplicity and portability , cell-free systems have become an increasingly important tool in iGEM and synthetic biology more broadly.

Our world has entered a new era of infectious diseases, where emerging, re-emerging, and endemic pathogens spread quickly, aided by increased international air travel and global warming. At iGEM, teams are tackling infectious diseases by using the tools of synthetic biology to reduce disease transmission, prevent future epidemics and pandemics, and save lives.

The future of the fashion and cosmetics industries may well lie in the hands of the future leaders of synthetic biology. These consumer-driven industries touch the lives of almost everyone on earth, but they also use massive amounts of raw materials and have an immense negative impact on the environment. At iGEM, teams are using synthetic biology to help move the fashion and cosmetics industries into a new, more sustainable, and animal cruelty-free era. Here are just a few examples of iGEM team projects that could usher in the next revolution in fashion and cosmetics.

Rare Disease Day is observed on the last day of February to raise awareness about rare diseases and improve access to treatment and medical representation. This article covers the barriers in therapy progress, communication and how are iGEM teams tackling rare diseases with synthetic biology

Take a looking how iGEM Teams from around the world are restoring Earth's health applying the tools and techniques of synthetic biology for Bioremediation.

Teams that participate in the iGEM Competition are pioneers of synthetic biology, and these grants empower teams to secure funding for impactful projects in responding to climate change and biodiversity loss, enhancing human health, improving agriculture production and food security, scaling up the sustainable industrial production, and many other critical challenges.

Software plays a transformative role in driving advances in synthetic biology. From designing biological systems and automating lab equipment, to managing collaborations and analyzing vast amounts of data, software underpins many of the essential tasks in making biology easier to engineer.

The iGEM team wiki is the primary means by which teams communicate their entire project to the world. The wiki is essentially a website that provides background information, describes project goals, and shows experimental results. Like other forms of scientific publication, the wiki also includes references to acknowledge the work of previous iGEM teams and other research groups that have helped inform the current project. Importantly, the team wiki has been a key deliverable since iGEM first became an international competition in 2005, and is archived so it can be accessed by future teams and iGEM community members.

While all iGEM teams push the boundaries of synthetic biology, teams who undertake plant projects must overcome a challenge that is particular to plants – namely, that plants take a long time to grow. One reason iGEM teams are successful in pioneering plant synthetic biology is because the teams that have come before have expended effort to get plants to grow within the timeframe of an iGEM Competition season. In honor of the 20th year of iGEM, we thought we’d take a look back on the achievements of some of the teams that have pioneered plant synthetic biology.

Hardware, Software, Wetware – all are encompassed within the Design-Build-Test-Learn cycle of synthetic biology. In honor of 20 years of iGEM, we’d like to feature the Hardware developed by iGEM teams.

Neurodegenerative diseases comprise a broad spectrum of disorders resulting from the gradual deterioration of cells and connections within the nervous system, crucial for functions such as movement, coordination, strength, sensation, and cognition. Explore how iGEM team’s have tackled the disease through their innovative diagnostic and therapeutic solutions.

Synthetic biology holds tremendous promise for addressing global challenges, but like all powerful technologies, there also are risks of accidental or deliberate misuse that could cause harm. In honor of the 20th year of iGEM, I’d like to take a look back on some of the highlights of iGEM’s history in building a strong culture of responsibility for biosafety and biosecurity.

Twenty years ago, scientists were using an ad hoc approach to assemble genetic constructs, which required a lot of time and did not always work as anticipated. Tom Knight, an engineer by training, thought that applying standard engineering mechanisms could make the assembly of genetic constructs more reliable. And so, in 2003, Tom proposed an assembly method for standard biological parts, or “BioBricks”.

We’re 250 years into the industrial revolution, which is about being good at energy. We’re 70 years into the computer revolution, which is about being good at information. Now we’re at the beginning of the next revolution, which is about being good at matter, and the best tool for that is biology.

Industrial scale-up helps bridge the gap between laboratory experiments and real-world implementation by addressing technical, economic, and practical challenges. Because industrial scale-up will require significant innovations if synthetic biology is to continue being a game-changing industry, the iGEM Competition has an entire Village dedicated to the challenges of industrial scale-up. 

This year, iGEM is introducing three new Villages – Agriculture, Bioremediation, and Space. Though iGEM teams have worked on projects in these areas for many years, this will be the first time teams will be gathered together within these official Villages. 

Ever since I worked on the Astroshield project with my teammates on the Sao_Carlos-Brazil 2019 iGEM team, I’ve been fascinated with how synthetic biology applied to space exploration can yield important insights for making life better here on Earth.

The iGEM 2022 teams have done amazing work in translating their projects into commercially viable products and services that could change the lives of many people by improving health, or combatting climate change, or addressing many other important, urgent world problems.

Tomorrow (November 10) is World Science Day for Peace and Development, a day established by the United Nations to recognize the importance of science in society and the need to inform the public about the relevance of science in their lives and to engage them in discussions on emerging scientific issues. In honor of World Science Day for Peace and Development, we’d like to highlight the nominees and winners of the Best Sustainable Development Impact award in the 2022 iGEM Competition.

In 2012, George Church, Yuan Gao, and Sriram Kosuri published their work “Next Generation Digital Information Storage” in the journal Science. Using DNA's four-letter nucleotide code of A, G, T, and C to encode the 0s and 1s of a digitized file, they were the first to demonstrate that DNA could be used as a storage medium. Fast forward to today, and you’ll see numerous developments in reading and writing different forms of data on DNA to make DNA storage more efficient and cost effective.

Antibiotic resistance - the most impactful silent pandemic of the century. It's astonishing to see how iGEM teams worked on different aspects of the problem in 2021, with some teams focused on detection of antibiotic resistance, while other teams developed new emerging technologies to kill the bacteria.

Last year, with the support of the Frederick Gardner Cottrell Foundation, we launched a first-of-its-kind initiative that provided grants to help 2021 iGEM teams take their projects further than ever before. Based on last year’s success, we are excited to continue this program for the 2022 season! Here are some examples from last year’s recipients of the iGEM 2021 Team Impact Grant.

Accessibility is key to iGEM’s new purpose of making sure that the field of synthetic biology, and all of the power that this technology holds, gets developed everywhere by everyone. In this episode of iGEM TV, I interview two special guests – Annika Shi from China and Cibele Zolnier from Brazil – both of whom are part of the iGEM Community’s Open Science & Accessibility Network. Check out this interview where we discuss some of the outstanding iGEM projects from the 2021 Jamboree that focused on accessibility.

World TB Day is March 24, which marks the day in 1882 when Dr. Robert Koch announced his discovery of the bacterium that causes TB – Mycobacterium tuberculosis – opening the way towards diagnosing and curing this disease. Despite being preventable and treatable, TB is still one of the world’s deadliest infectious diseases, second only to COVID-19 in 2020. This year the theme of World TB Day is “Invest to End TB. Save Lives”, reflecting the urgency to invest resources to end the global TB epidemic by 2030.

This Friday – March 4 – is World Engineering Day for Sustainable Development, a United Nations’ international day for celebrating engineers and engineering. It’s a day to recognize the critical role of engineers in achieving the UN Sustainable Development Goals (SDGs) to ensure that everyone has access to clean water, sanitation, reliable energy, and other basic human needs. In honor of World Engineering Day for Sustainable Development, we’d like to highlight the accomplishments of iGEM teams in engineering biological solutions towards the UN’s Sustainable Development Goals.

Every year, hundreds of fascinating projects are developed by iGEMers to face the pressing challenges of our time and innovate for the future. I invite you to check out my interview with Maarten Lubbers as we discuss projects from the iGEM 2021 season that focus on biodiversity conservation. These are very different projects using very different approaches by iGEM teams from different continents around the globe.

Last year, we introduced the Inclusivity Award to recognize excellence among iGEM teams working to create a more inclusive and representative scientific community. This special award honors teams that have made exceptional and thoughtful efforts to eliminate the barriers that prevent underrepresented groups from contributing to, participating in, or being represented by scientific research.

Breast Cancer Awareness month is honored every October in countries around the world to increase awareness, early detection, treatment, and palliative care. Last year, 2.3 million women were diagnosed with breast cancer and 685,000 women died from this disease.